Twitter chief executive Dick Costolo is stepping down and will be replaced on an interim basis from July 1 by co-founder Jack Dorsey, the company has said.
The move comes with the one-to-many messaging platform struggling to boost its user base after a much-anticipated public offering in 2013.
Costolo guided the San Francisco-based firm through its initial public offering, but growth has been disappointing and the company has yet to show a profit.
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Twitter said it formed a committee that will work with "a leading executive search firm to assist in conducting a global search which will consider both internal and external candidates" for CEO.
Dorsey said in the statement: "The future belongs to Twitter thanks in large part to Dick Costolo's dedication and vision."
In its latest earnings report, in April, Twitter said it had a net loss in the quarter of $162.4 million.
The company said the number of active monthly users rose above 300 million, but that figure has been growing a pace too sluggish for many investors, and below rivals in social networking.