The star couple will welcome First Lady Michelle Obama, movie mogul James Lassiter and Salma Hayek as part of an exclusive luncheon on October 25, said The Hollywood Reporter.
Guests will have to pay a USD 2,500 contribution to the Obama Victory Fund to grab a seat at the event, while those splashing out USD 10,000 will get the chance to meet the guest of honour, Michelle, and have a picture taken with her.
The Smiths are the latest celebrities to host a star-studded fundraiser for Obama - Gwen Stefani, George Clooney and Sarah Jessica Parker have already done their bit to help re-elect the President.
Obama will go up against chief rival Mitt Romney on US election day next month.