Seamer Chris Woakes grabbed four wickets while James Tylor notched an unbeaten half century to anchor England's six-wicket win over Pakistan in the third day-night international here.
Woakes's 4-40 skittled Pakistan out for a below-par 208 in 49.5 overs before Taylor scored 67 for his seventh fifty to help England to the target in 41 overs for a 2-1 lead in the four-match series.
Pakistan have one last chance to avoid their ninth series loss out of 11 in the United Arab Emirates (since 2009) when they play the final ODI in Dubai on Friday.
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England were outstanding in all three departments as they bundled Pakistan out on a flat pitch for a low total and then rode an unbroken 117-run stand for the fifth wicket between Taylor and Jos Buttler (49 not out).
Taylor smashed two boundaries off lanky paceman Mohammad Irfan and then clobbered a flat six to reach his fifty off 51 balls. In all he hit six boundaries and two sixes off 69 balls.
Buttler supplemented Taylor, hitting the winning six as the pair survived some anxious moments early on after Pakistan caught England at 93-4.
Irfan gave Pakistan an early breakthrough when he dismissed Jason Roy for seven while debutant left-arm spinner Zafar Gohar, included for the injured Yasir Shah, had Joe Root caught off a full toss for 11.
Alex Hales (30) and Eoin Morgan (35) added 60 for the third wicket before Gohar had the opener caught in the slips while Morgan was bowled by Shoaib Malik.
But Taylor and Buttler ensured no further loss and the victory.
It was a case of sloppy batting as Pakistan, who won the toss and batted, were derailed from 92-1 in the 20th over, losing their last nine wickets for just 116 runs.
Their cause was not helped by three unnecessary run outs of skipper Azhar Ali (36), Mohammad Rizwan (one) and Malik (16) with Woakes the main wicket taker.
It was only through a ninth-wicket stand of 26 between Wahab Riaz (33 not out) and Gohar (15) that Pakistan got past the 200-mark.