By Greg Roumeliotis and Ben Martin
LONDON (Reuters) - Takeda Pharmaceutical has made an indicative takeover proposal to British drugmaker Shire worth about 46.50 pounds a share, according to two sources with direct knowledge of the matter.
That would value London-listed Shire at about 43 billion pounds ($61 billion), according to Reuters data.
The move comes ahead of a deadline for the Japanese group to make a firm offer or walk away from the FTSE 100 company by April 25. Shares in Shire were up 5.3 percent at 39.59 pounds at 1032 GMT.
Takeda confirmed last month it was considering an offer for Shire, a rare disease specialist.
A spokesman for Takeda declined to comment and Shire did not return a request for comment.
($1 = 0.7039 pounds)
(Reporting by Greg Roumeliotis and Ben Martin; Editing by Jason Neely and Mark Potter)
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