The three major US stock indexes had earlier traded in a tight range, supported by a gain of more than 12% in Cisco Systems
But the S&P 500 finished near its session low following the comments from John Williams, the president of the Federal Reserve Bank of San Francisco, who also said the Fed could end its bond purchases later this year, assuming the labor market continues to grow stronger. Williams is not a voter on the Fed's policy-setting panel this year.
"When a Fed governor is out there and mentions this possibility, it does spook the market a little because I don't think anybody quite knows how the stock market is going to react once (the stimulus) is taken away," said Tim Ghriskey, chief investment officer of Solaris Group in Bedford Hills, New York.
The Fed's purchases of $85 billion a month in bonds has been a significant driver of the rally in equities that has taken indexes to record highs and pushed the S&P 500 up nearly 16% this year.
Analysts also said the comments could have been viewed as a reason to take a pause after such a strong run-up in stocks.
"It turned a boring day into a bit of profit taking," Ghriskey said.
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Other Fed officials on Thursday called for the central bank to stop buying mortgage-backed bonds, citing improvement in the housing market.
The Dow Jones industrial average dropped 42.47 points, or 0.28%, to close at 15,233.22. The Standard & Poor's 500 Index fell 8.31 points, or 0.50%, to end at 1,650.47. The Nasdaq Composite Index slipped 6.37 points, or 0.18%, to finish at 3,465.24.
Earlier, the Dow reached an all-time intraday high at 15,302.49.
The Nasdaq fared better than the other two major indexes as Cisco shot up 12.6% to $23.89 after the network equipment maker posted a higher-than-expected quarterly profit and said current-quarter revenue could increase.
Dell
In other news after the close, J.C. Penney
Early in the day, economic data set a lackluster tone in markets as data from the Philadelphia Federal Reserve showed factory activity in the mid-Atlantic region contracted, while the Commerce Department reported that US housing starts plummeted 16.5% in April. New claims for jobless benefits unexpectedly jumped last week.
However, investors had speculated that soft underlying inflation also means the Fed has room to continue its economic stimulus.
Wal-Mart Stores Inc
Tesla Motors Inc
Volume was roughly 6.45 billion shares on the New York Stock Exchange, the Nasdaq and the NYSE MKT, compared with the year-to-date average daily closing volume of about 6.34 billion.
Decliners outnumbered advancers on the NYSE by a ratio of 3 to 2, while on the Nasdaq, 14 stocks fell for nearly every 11 that rose.