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Those vaccinated before getting Covid at lower risk of post-discharge death

"Participants who had received at least one dose of the anti-SARS-CoV-2 vaccine before their COVID-19 infection had a lower risk of post-discharge mortality," the study said

Photo: Bloomberg

Photo: Bloomberg

Press Trust of India New Delhi

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A one-year follow-up of COVID-19 patients discharged from hospitals found that participants who received at least one dose of anti-Covid vaccination before contracting the coronavirus infection had a lower risk of post-discharge mortality, according to a study by ICMR.

Of the 14,419 participants who were followed up at least once between four weeks and one-year post-discharge, 942 (6.5 per cent) had died and the remaining (93.5 per cent) were reported alive at any contact during one year of follow-up.

They were from 31 hospitals across the country.

"Participants who had received at least one dose of the anti-SARS-CoV-2 vaccine before their COVID-19 infection had a lower risk of post-discharge mortality," the study said.

 

Vaccination prior to the COVID-19 infection (at least a single dose) provided 60 per cent protection against post-discharge mortality.

People older than 40 years, men with co-morbidities and those who had moderate to severe COVID-19 to begin with had a higher chance of all-cause mortality within one of discharge from hospital.

The study "Determinants of post-discharge mortality among hospitalised COVID-19 patients: Nested matched case-control analyses from the National Clinical Registry for COVID-19" has been published in the Indian Journal of Medical Research (IJMR).

It was conducted by the National Clinical Registry for COVID-19 study team.

The team conducted nested matched case-control analyses to evaluate the factors related to one-year post-discharge mortality.

The country's apex research body, Indian Council of Medical Research (ICMR), has been maintaining the National Clinical Registry for COVID-19 at 31 centres across the country, where all hospitalised COVID-19 patients were periodically contacted by telephone till one year after discharge.

Data collected till February 2023 were included in this analysis.

Emphasis was put on the 18-45 yr of age to understand the factors associated with post-discharge death in young adults. Factors associated with death in them after discharge were similar to the ones observed in other age brackets.

Prior anti-COVID-19 vaccination did lend some protection against all-cause post-discharge death in this age group, although this cannot be claimed conclusively as the association was not statistically significant.

The limitations of the current investigation include reliance on telephonic follow-up, which could have led to under-reporting of the symptoms. The present analyses only included patients who were hospitalized due to COVID-19, and consequently, the findings cannot be generalized to all patients who had COVID-19, the study stated.

The ICMR is also conducting a multicentric hospital-based matched case-control study on the effect of COVID-19 vaccines on thrombotic events among the 1845-year-old population in India in 2022 and on factors associated with sudden deaths among adults aged 1845 years in India.

(Only the headline and picture of this report may have been reworked by the Business Standard staff; the rest of the content is auto-generated from a syndicated feed.)

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First Published: Aug 21 2023 | 6:42 PM IST

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